How to cook butternut squash? Cooking butternut squash is simple and versatile. To start, preheat the oven to 400°F (200°C). Peel the squash, remove the seeds, and cut it into cubes or slices. Toss the squash with olive oil, salt, and pepper, or your choice of seasoning. Arrange the pieces on a baking sheet in a single layer. Roast in the preheated oven for 25-30 minutes or until the squash is tender and caramelized, flipping halfway through. Alternatively, you can steam, boil, or sauté butternut squash for various recipes like soups, stews, salads, or as a side dish. Its sweet, nutty flavor and creamy texture make it a delightful addition to many dishes.